Experimental Allergic Encephalomyelitis. A Useful Model for Multiple Sclerosis

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Experimental allergic encephalomyelitis: a misleading model of multiple sclerosis.

Despite many years of intensive research, multiple sclerosis (MS) defies understanding and treatment remains suboptimal. The prevailing hypothesis is that MS is immune mediated and that experimental allergic encephalomyelitis (EAE) is a suitable model to elucidate pathogenesis and devise therapy. This review examines critically the validity that EAE is an adequate and useful animal model of MS ...

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multiple sclerosis (ms) is a progressive and autoimmune neurodegenerative disease of the central nervous system (cns). this disease is recognized through symptoms like inflammation, demyelination and the destruction of neurological actions. experimental allergic encephalomyelitis (eae) is a widely accepted animal model for ms. eae is created in animals by injecting the tissue of myelin basic pr...

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ژورنال

عنوان ژورنال: Journal of Neuropathology and Experimental Neurology

سال: 1984

ISSN: 0022-3069

DOI: 10.1097/00005072-198411000-00010